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The 15 Best Acne Spot Treatments to Zap Zits, Fast
These top picks come dermatologist-approved.
I've had combination skin my entire life, so it's hard for me to imagine a time when I wasn't in need of one of the best acne spot treatments. While I try to maintain a regular skincare routine—the usual cleansing, exfoliating, moisturizing, and SPF application—sometimes acne is out of my control, which is why I always keep a spot treatment handy. Depending on your needs, many of these staples feature fast-working formulas (some that combat zits in a mere four hours) that don't waste time getting to the root of your breakouts.
"One of the most common active ingredients used to treat acne is salicylic acid, or beta hydroxy acid," board-certified dermatologist Corey L. Hartman tells BAZAAR.com. "Salicylic acid works well for smoothing skin with acne as it minimizes irritation, and is a chemical exfoliant. Salicylic acid will help expedite cellular turnover and also can reduce swelling and redness."
Shop the Best Acne Spot Treatments
For those dealing with blackheads, treatments featuring salicylic acid can help remove excess sebum (also known as oil) and dirt from your pores. And if you most commonly get whiteheads, products with benzoyl peroxide are a great option for clearing skin. "Benzoyl peroxide is an anti-inflammatory that works to treat mild to moderate acne by killing p.Acnes bacteria that causes acne," Hartman continues. "It also helps to prevent acne by exfoliating skin while minimizing redness and inflammation."
The expert also notes that benzoyl peroxide can help reduce inflammation from cystic acne, larger, sometimes more painful pimples that occur deep under the skin. Plus, redness reducing ingredients like niacinamide, azealic acid, and tea tree oil, are often found in these effective treatments, and help keep skin balanced as acne is targeted.
If you have active breakouts like I do, you'll be glad to hear that many spot treatments are gentle enough to use everyday. To help get rid of pesky or unexpected zits even faster, we've rounded up some of the best acne spot treatments that are not only easy to use, but highly effective in shrinking pimples down to size.
Related: Road Test: We Tried the SolaWave Bye Acne: 3 Minute Light Therapy Spot Treatment
Mario Badescu Drying Lotion
Pros
- Works quickly
Cons
- May be irritating for sensitive skin
There's a reason over 31,000 shoppers are raving about this pink drying lotion from Mario Badescu: It combines acne-fighting ingredients like salicylic acid and sulfur to get rid of zits overnight.
One satisfied customer writes:
"This stuff is great. No shaking. Dip the Q-Tip to the pink and dab. Sleep. Wash off in the morning. Watch your face look amazing." —Kay A.
| Key ingredients: | Calamine, camphor, sulfur, zinc oxide, salicylic acid |
|---|
La Roche-Posay Effaclar Duo Dual Action Acne Spot Treatment Cream
La Roche-Posay Effaclar Duo Dual Action Acne Spot Treatment Cream
Pros
- Safe for sensitive skin
Cons
When it comes to the acne spot treatment he most typically recommends to his clients, Hartman reaches for this popular option from La Roche-Posay. "I recommend La-Roche Posay Effaclar Duo Acne Treatment, which uses micronized benzoyl peroxide to penetrate deeper into the skin to clear active acne," he adds.
| Key ingredients: | Benzoyl peroxide, beta-lipohydroxy acid |
|---|
Kinship Pimple Potion Retinal + Salicylic Acne Treatment
Kinship Pimple Potion Retinal + Salicylic Acne Treatment
Pros
- Gentle
Cons
As a beauty enthusiast, I've tried my fair share of spot treatments over the years, but this one from Kinship is one I gravitate back to again and again. Not only does it work quickly to minimize pimples, but it also can be used on the entire face if you're dealing with a particularly bad breakout.
One satisfied customer writes:
"I started using this a week ago and it really helps. It doesn’t dry my skin out, and reduces the look of a zit by the next day. I don’t feel a burn or anything when putting it on, but still does the job—it’s very gentle! Quickly absorbs too so you could apply makeup after, etc." —Elizabeth
| Key ingredients: | Retinal, bakuchiol, salicylic acid, plant-based probiotics |
|---|
SkinCeuticals Blemish + Age Defense Salicylic Acid Acne Treatment
SkinCeuticals Blemish + Age Defense Salicylic Acid Acne Treatment
Pros
- Reduce the appearance of fine lines
Cons
- Best for mature skin
This top-rated serum can be used as a spot treatment to minimize acne while improving the appearance of fine lines and hyperpigmentation at the same time.
One satisfied customer writes:
"I recently added this to my SkinCeuticals routine and love it. I am 41, and have cystic acne on my chin and it has cleared up completely!" —Rebecca
| Key ingredients: | Alpha hydroxy acids, glycolic acid, salicylic acid |
|---|
Tula Go Away Acne Spot Treatment
Pros
- Works quickly
Cons
The name of this popular treatment says it all: Not only is it powered by benzoyl peroxide to quickly fight breakouts, but it also uses ingredients like niacinamide, azelaic acid, and tea tree oil to soothe redness and irritation.
One satisfied customer writes:
"I'm actually in awe of this product. I had some hormonal blemishes on my face and I used this product twice a day for two days. The pimples were raised, irritated and red at first, now three days later, they are essentially gone!! I'm seriously amazed. I've tried other acne spot treatments and none have ever worked this well." —Riley G.
| Key ingredients: | Probiotic extracts, benzoyl peroxide, tea tree oil, licorice, niacinamide |
|---|
Starface Hydro-Stars + Big Yellow
Starface Hydro-Stars + Big Yellow
Pros
- Mess-free
Cons
For a set it and forget it option for acne, reach for these fun hydrocolloid patches from Starface. These stickers work overtime to shrink zits while protecting them from the elements. I love using them in my nighttime routine for ultimate beauty rest.
One satisfied customer writes:
"They work great! I noticed a visible difference after using the Hydro-Stars. Also the packaging is super cute and convenient. Highly recommend!" —Jenn W.
Sunday Riley Saturn Sulfur Spot Treatment
Sunday Riley Saturn Sulfur Spot Treatment
Pros
- Great for stubborn breakouts
Cons
- May be too intensive for sensitive skin
Whether you decide to use this treatment in dabs or all over your face, your breakouts are no match for its powerful sulfur formula.
One satisfied customer writes:
"I am completely obsessed with many of Sunday Riley’s products, and this is one of them. It's hands down the most effective spot blemish treatment I have used. I put a dab of the green cream on the blemish, leave it on over night, and within 24 hours it's significantly dried up. Decreases redness. The sulfur smell is not my favorite, but the product does the job." —shadowmoonbeam
Neutrogena On-The-Spot Acne Spot Treatment
Neutrogena On-The-Spot Acne Spot Treatment
Pros
- Budget-friendly
Cons
We count Neutrogena's On-The-Spot Acne Spot Treatment as one of the OG pimple fighters. Its effective benzoyl peroxide formula absorbs quickly, and doesn't leave skin feeling dry once its applied.
One satisfied customer writes:
"Pimples are visibly better after just one application. Got this for my teenager. He loves it too." —Tan X.
| Key ingredients: | Benzoyl peroxide |
|---|---|
| Color | White |
SolaWave Bye Acne: 3-Minute Pimple Spot Treatment
SolaWave Bye Acne: 3-Minute Pimple Spot Treatment
Pros
- Mess-free
Cons
- Can only be used once on each targeted area per day
I previously tested SolaWave's Bye Acne: 3-Minute Pimple Spot Treatment, which combines blue and red light technology to minimize zits in a literal flash. It's an easy-to-use tool that's perfect for managing random acne flare-ups, whether you're at home or on the go.
One satisfied customer writes:
"I’ve been using the device for a few weeks now and it is so good for getting rid of breakouts. It’s not a bad price for a light therapy device and it’s totally worth it!!" —Cait
Dr Dennis Gross DRx Blemish Solutions Acne Eliminating Gel
Dr Dennis Gross DRx Blemish Solutions Acne Eliminating Gel
Pros
- Contains niacinamide to reduce redness
Cons
- May be too intensive for sensitive skin
This beloved gel uses a combination of two percent salicylic acid, retinol, and glycolic acid to fight acne, and also happens to work as an astringent to help control oil production.
One satisfied customer writes:
"This product is the best when it comes to pimples. As soon as I get one, I put this on and it’s gone the next day. This product is excellent! And a must to have in your toiletries." —Sheriann
| Key ingredients: | Alpha hydroxy acids, glycolic acid, salicylic acid, niacinamide |
|---|
First Aid Beauty Pharma BHA Acne Spot Treatment Gel
First Aid Beauty Pharma BHA Acne Spot Treatment Gel
Pros
- Contains aloe and oatmeal to soothe irritation
Cons
If you tend to develop whiteheads in addition to acne, this top-rated treatment gel from First Aid Beauty might be next up on your holy-grail skincare list. It uses two types of salicylic acid—two percent of the ingredient, along with its natural derivative, willow bark extract—to quickly clear your complexion.
One satisfied customer writes:
"Works well! Helps cut break out time in half or better." —Felicia
| Key ingredients: | Salicylic acid, glycolic acid, papaya, willow bark extract |
|---|
Murad Rapid Relief Acne Spot Treatment
Pros
- Invisible
Cons
Murad's hardworking spot treatment aims to minimize breakouts in four hours, and features a clear formula that won't stick out like a sore thumb under your foundation and concealer.
One satisfied customer writes:
"This product is great. Applied at night and by morning, redness was gone. Blemishes reduced immensely. Highly recommend." —Shauna
| Key ingredients: | Salicylic acid, pine and thyme-inspired complex, horse chestnut, oat |
|---|
The Inkey List Succinic Acid Acne Treatment
The Inkey List Succinic Acid Acne Treatment
Pros
- Vegan
Cons
This treatment uses a blend of succinic and salicylic acids plus sulfur powder to not only get rid of existing acne, but also helps prevent future breakouts from occurring. And since it also features hyaluronic acid, it'll leave your skin looking and feeling just a bit plumper.
One satisfied customer writes:
"I will definitely buy this again, it really works. I put a small amount on bumps and blemishes before bed and they are definitely smaller in the morning. And they heal more quickly." —Franx
| Key ingredients: | Succinic acid, sulfur powder, salicylic acid, hyaluronic acid |
|---|
Renée Rouleau Night Time Spot Lotion
Renée Rouleau Night Time Spot Lotion
Here's a nighttime spot lotion from Renée Rouleau that works while you sleep to fight acne and whiteheads. As an added bonus, it can even be used to treat backne and chest breakouts.
One satisfied customer writes:
"Best lotion to dry unwanted pimples I have ever used." –Carol E.
Beautycounter Countercontrol SOS Acne Spot Treatment
Beautycounter Countercontrol SOS Acne Spot Treatment
Pros
- Top-rated
Cons
This treatment gel exclusively uses maximum strength salicylic acid to target unwanted breakouts, and also contains a wintergreen and rosebay willow complex that helps keep skin balanced.
One satisfied customer writes:
"I’ve struggled with stress acne that pops up after a long hard day of work, and putting this on before bed wipes them out the next day without drying me out!" —Nikki M.
| Key ingredients: | Salicylic acid, wintergreen, and rosebay willow |
|---|
Meet the Experts
- Corey L. Hartman, M.D., F.A.A.D, is the founder of Skin Wellness Dermatology in Birmingham, Alabama.
When in your routine should an acne spot treatment be applied?
Spot treatments can be applied during either your morning or evening skin routines, but many beauty enthusiasts most commonly use them in the daytime. "I personally use a spot treatment after applying moisturizer, but before applying sunscreen," Hartman says. "You can also spot treat right before applying moisturizer and sunscreen."
What are some red flags that an acne spot treatment is too intense?
According to Hartman, some clear indicators that a product may not be ideal for you are, "If your skin feels uncomfortable—too tight, painful, or tender to the touch—or is dry and flakey, your spot treatment may be too intense," he advises. "You can try using less of the spot treatment, or space out the times per week you use it, or try and entirely different product. Your board-certified dermatologist can help make recommendations on products and frequency of use, too."
Why trust Harper's BAZAAR?
For more than 150 years, Harper’s BAZAAR has been the preeminent fashion and beauty resource for women at every age. We cover what’s new and what’s next in beauty by working with the world’s leading authorities in dermatology, plastic surgery, cosmetics, skincare, haircare, and fragrance. Every story we publish has been thoroughly researched and vetted by our team of beauty editors and industry experts.
Tiffany Dodson is currently the associate beauty commerce editor at Harper’s Bazaar, where she specializes in trend forecasting, building relationships with major and emerging brands, and crafting shopping stories—from holiday gift guides to product road tests. Tiffany's work has previously been featured in outlets like SELF, Bustle, and Teen Vogue, and she's been quoted as a commerce and beauty expert in publications and platforms like The Business of Fashion and NPR’s Life Kit podcast.
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